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The Study of Osteoporotic Fractures (SOF) was initially established to identify the risk factors associated with osteoporotic fractures in postmenopausal women aged 65 and older. Over time, the scope of the study expanded to include assessment of sleep, cognitive function, osteoarthritis, breast cancer, cognitive function and healthy aging.

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Other NIA Studies

Longitudinal and clinical studies on aging supported by the National Institute on Aging have generated collections of biospecimens and related phenotypic and clinical data to allow better understanding of the aging process and to promote advances in the development of prognostics, markers, and therapeutics for aging-related conditions.

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About the NIA

The National Institute on Aging (NIA) at the National Institutes of Health (NIH) leads the federal government in conducting and supporting research on aging and the health and well-being of older people. Our research ranges from the study of basic cellular changes that accompany the aging process to the examination of the biomedical, social, and behavioral aspects of growing older. Our main goal is to understand the nature of aging and the aging process, and diseases and conditions associated with growing older, in order to extend the healthy, active years of life.

Learn more about the NIA’s mission and strategic directions for aging research at