Frequently Asked Questions
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Frequently asked questions about the AgingResearchBiobank can be found below:
About the AgingResearchBiobank
What is the purpose of having the AgingResearchBiobank?
The National Institute on Aging (NIA) at the National Institutes of Health (NIH), U.S. Department of Health and Human Services (HHS), conducts and funds various longitudinal and clinical studies on aging that generate or have generated a collection of biospecimens and related phenotypic and clinical data. In 2018, the NIA's Division of Geriatrics and Clinical Gerontology established the AgingResearchBiobank to provide a state-of-the-art inventory system for the storage and distribution of these collections to the broader scientific community. Over the years, study collections have made significant contributions to public health and will continue to do so. Aging research will be expanded through the use of such collections to address new promising scientific questions targeting the development of prognostics, markers, and therapeutics for conditions related to aging and to provide a better understanding of the aging process. Collections included in the AgingResearchBiobank were built over many years from studies that carefully selected subjects and are available in a finite quantity. Each biospecimen is unique and cannot be replaced. Together with the opportunity to potentially pool data across study collections significantly increases the value and power of future research findings from the resources offered by the AgingResearchBiobank.
What are the components of the AgingResearchBiobank?
The AgingResearchBiobank includes two separate contract-funded components that work together to store data (including images) and biospecimens from relevant NIA-funded studies.
- Biologic Specimens (Biorepository) - Receives biospecimens from different study collections, stores the biospecimens under optimal conditions, and distributes them to qualified investigators.
- Data Repository - Serving as the data coordinating center for the AgingResearchBiobank, it receives, archives, maintains and distributes databases and images from different study collections. The Data Repository also analyzes stored data and images in response to inquiries, assists ongoing studies in preparing data and images for eventual archiving, coordinates cross-referencing between the two components of the AgingResearchBiobank, and manages the AgingResearchBiobank website.
Submitting Resources from NIA Grants
Eligibility for Submission of Data (including images) and/or Biospecimens to the AgingResearchBiobank
Who can submit biospecimens and data?
Only relevant NIA-funded studies designated by NIA will be eligible to submit biospecimens and/or data collections (including images) to be hosted by the AgingResearchBiobank. NIH policy is that the unique resources developed through NIH funding are to be shared with the research community, to the extent that sharing of clinical data (including images) and materials is practical. Therefore, all current and complete multi-site NIA-funded studies should have a plan or should develop a plan for sharing data (including images) and biospecimens that complies with current NIH and NIA policies (https://sharing.nih.gov/data-management-and-sharing-policy/about-data-management-and-sharing-policies/data-management-and-sharing-policy-overview#after). Wherever appropriate, the AgingResearchBiobank should be used to facilitate sharing.
Submitting Data (including Images) to the AgingResearchBiobank
What data should be sent to the Data Repository?
In general, the repository should receive all of the data (including images) being collected or created by the Study Data Coordinating Center, provided that the subject has consented to having his/her data included in the repository. However, no personal identifiers should be sent to the repository, and data (including images) may need to be transformed in some way to ensure that no personal identifiers are deposited.
When should the file linking biospecimens to the clinical data be provided?
A linkage file is a list that associates biological biospecimens (or images) with the relevant clinical data by matching the IDs that were used for the biospecimens (or images) to the deidentified subject IDs that were used for the clinical records for all of the study subjects. The linkage file should be provided by the Study Data Coordinating Center at the time the clinical data (including images) are delivered to the AgingResearchBiobank for completed studies.
What interaction will the Study Data Coordinating Center have with the AgingResearchBiobank before data are sent?
The AgingResearchBiobank will work with the Study Data Coordinating Center to help prepare the data package for archiving. AgingResearchBiobank personnel will consult with the Study Data Coordinating Center to develop appropriate documentation that is comprehensive enough to allow investigators not familiar with the data to use them. In addition, they will familiarize themselves with the database and its architecture in preparation for archiving and distribution.
Should protected health information be sent to the AgingResearchBiobank?
In general, the AgingResearchBiobank should only get limited datasets as defined under HIPAA regulations. In some cases, the AgingResearchBiobank personnel may provide advice to Study Data Coordinating Centers on how to transform data to prevent transmission of protected health information. Guidance is also available on methods to de-identify protected health information according to HIPAA (https://www.hhs.gov/hipaa/for-professionals/special-topics/de-identification/index.html)
Submitting Biospecimens to the AgingResearchBiobank
Which biospecimens should be sent to the AgingResearchBiobank and when should those biospecimens be sent?
In general, the AgingResearchBiobank should be used to store biospecimens that are not being used for the active conduct of the study. Whenever practical, part of each biospecimen should be designated for the AgingResearchBiobank and stored until the end of the study's lifespan or designated funding period.
Who will be in charge of the biospecimens at the AgingResearchBiobank?
Upon submission, the National Institute on Aging (NIA) assumes custodianship of the biospecimens. The NIA Official responsible for the biorepository is Rosaly Correa-de-Araujo, MD, MSc, PhD, FAC COR Level III who serves as the Program Officer/Contracting Officer Representative (COR) for the AgingResearchBiobank. The AgingResearchBiobank likewise becomes the primary point of contact for requesting use of the biospecimens.
Can the AgingResearchBiobank do aliquoting?
Yes, the biobank can aliquot biospecimens. There will be an additional charge for this service. (https://agingresearchbiobank.nia.nih.gov/costs/)
Can the AgingResearchBiobank serve as the primary receipt point for biospecimens, processing, aliquoting and shipping biospecimens out to various analysis laboratories during the study?
The AgingResearchBiobank cannot be used as a study’s central receiving laboratory. That work is generally funded for the active life of a study and each study should have its own plan for biospecimen processing and storage until a study is completed and a decision is made to deposit the study collection in the Biobank. The AgingResearchBiobank then receives, stores, maintains and distributes/shares biospecimens with secondary researchers upon study completion.
Can the AgingResearchBiobank carry out biospecimen processing or routine clinical analyses?
The AgingResearchBiobank is not intended to serve as a clinical laboratory, but it can, when needed, conduct some specific laboratory testing such as tissue integrity testing.
Obtaining Biospecimens and Data (including Images) for Research
Available Biospecimens and Data (including images)
What types of materials are available?
The list of studies and the associated biospecimens, and data (including images) available can be found at the Study Search page. (https://agingresearchbiobank.nia.nih.gov/studies/)
If my only goal is to use a dataset to demonstrate the statistical methodology and I do not plan to draw any scientific conclusions using the dataset, do I need to go through the IRB process?
For any level of access to the data, you must have your institution's IRB approval. In some cases, institutions may provide a waiver.
Do you have genotype data available?
Large scale genomic data will become available in the next few months. A proper announcement will be released when the data become available for access by qualified investigators/research proposals.
Eligibility for Access
Who can access stored materials?
Principal Investigators (i.e., Senior Investigators or other individuals with the authority to sign the Outgoing Human Resources Transfer Agreement (OHRTA) or Outgoing Human Data Transfer Agreement (OHDTA) as the responsible party for the research being proposed) must register for an account in order to submit a Request for Materials (data (including images) and/or biospecimens) and, if approved by the Biobank’s scientific review committees, to download the data.
Can I share AgingResearchBiobank materials with other researchers?
The Principal Investigator (PI) is responsible for oversight of Approved Users of AgingResearchBiobank materials, and may include additional Approved Users within his/her institution to be included in the Outgoing Human Resources Transfer Agreement (OHRTA) or Outgoing Human Data Transfer Agreement (OHDTA). The OHRTA/OHDTA holds the PI and the Institutional Signing Official at the recipient institution responsible for adhering to the terms of the agreement, including maintaining AgingResearchBiobank materials in a secure manner within the institution.
If your project involves collaborators from an outside institution, the collaborator(s) must complete a separate request and sign an OHRTA/OHDTA along with an Institutional Signing Official at their own institution prior to accessing any AgingResearchBiobank data (including images) and/or biospecimens.
Can the study group that collected the biospecimens retrieve some of the biospecimens stored in the AgingResearchBiobank?
Secondary use of biospecimens by a researcher from the original study group will follow the same guidelines and procedures as other researchers.
Can non-U.S. investigators apply to use biospecimens and data (including images) from the AgingResearchBiobank?
The request requirements are currently the same as for US applicants. Although it is conceivable that there will be certain biospecimens and data (include images) collected in specific studies that are restricted to U.S. investigators by the terms of the study or of the participant's consent. At this time, there are no such studies.
Restrictions in support of current security directives resulted in NIH implementation of a technical update to enhance security measures focused on protecting data provided by NIH Controlled-Access Data Repositories (CADRs). Specifically, as of April 4, 2025, NIH is prohibiting access to and ending any remaining ongoing projects involving NIH CADRs and associated data by researchers and institutions located in countries of concern. Please see Guide Notice NOT-OD-25-083 for more details.
Can commercial organizations apply to use biospecimens and data (including images) from the AgingResearchBiobank?
Yes. The request process is open to all organizations interested in using biospecimens or data (including images) for research, although it is conceivable that there will be certain materials collected in specific studies that are restricted from commercial use by the terms of the study or of the participant's consent.
Are there special provisions for biospecimens collected by international consortia?
For biospecimens collected by international consortia, applications for use of biospecimens and data (including images) will be considered regardless of the geographical location of the applicant institution or researcher, currently subject to the exclusions in NOT-OD-25-083.
Cost for Access
Is there a charge for biospecimen requests or data requests?
All requestors will be invoiced for biospecimens according to the prices outlined on our costs page. (https://agingresearchbiobank.nia.nih.gov/costs/) This page also contains the policies for submitting payment, including a requirement that all requests pre-pay prior to the AgingResearchBiobank beginning preparation of the shipment.
Data packages are generally provided at no cost.
I am an Ancillary Biospecimen Requestor, will I be charged for my biospecimen request?
Yes. All requestors are charged the same prices to receive biospecimens, regardless of their affiliations.
I have a request for 0.5ml of serum from every subject in a study at every time point. Will I be charged for data support?
No, this is a typical biospecimen request and is within the scope of support that the AgingResearchBiobank provides for free.
I need tables of demographic characteristics to submit along with my grant proposal for funding to use the biospecimens I'm requesting from the AgingResearchBiobank. Will I be charged for data support?
No, this is a typical data support request and is within the scope of support that the AgingResearchBiobank provides for free.
I do not have an analyst but I need to prepare complex tables of multiple characteristics I plan to explore using biospecimens I'm requesting from the AgingResearchBiobank. Will I be charged for data support?
Yes, you are likely to need to pay for additional support in order to define and complete your tables. An estimate will be provided once the work is defined.
I have a specific set of subject and specimen IDs that I would like to request from the AgingResearchBiobank. Will I be charged for data support?
Yes. This is not a typical biospecimen selection and will require additional support. An estimate will be provided once the work is defined.
Applying for Access
How do I obtain data, images, or biospecimens from the Repository?
To request data, images, and/or biospecimens, go to the Request for Materials page: https://agingresearchbiobank.nia.nih.gov/requests/request-for-materials/create/
Requestors will need to provide the following:
- AgingResearchBiobank Online Request Form
- Protocol (See Glossary for more information)
- IRB Approval (or waiver)
- Collaborator Attestation (example)
- Curriculum Vitae (CV)/Resume
- Proof of Funding
- Signed copy of the Outgoing Human Resources Transfer Agreement (OHRTA) or Outgoing Human Data Transfer Agreement (OHDTA) provided to you by AgingResearchBiobank staff after submission of the Online Form
On the Outgoing Human Resources Transfer Agreement (OHRTA) or Outgoing Human Data Transfer Agreement (OHDTA) forms, who should provide the Authorized Signature for my institution?
An Institutional Signing Official (SO) from your institution should provide this signature. An SO has institutional authority to legally bind the institution in grants administration matters. The individual fulfilling this role may have any number of titles in the grantee organization. For most institutions, the Signing Official (SO) is located in its Office of Sponsored Research or equivalent.
Is funding required to access AgingResearchBiobank materials?
Funding is required for requests that include biospecimens. This can include NIH grant funds, institutional/departmental funds, NIH intramural funds, private foundation funds, funding outside of the United States, industry funds, non-NIH federal funds, state funding, etc.
You may submit a request for biospecimens if you do not have funding currently available, but plan to apply to a funding opportunity. Once suitable specimens have been identified, the request will be put on hold until the outcome of your funding application has been determined. AgingResearchBiobank can provide a letter of biospecimen availability for inclusion in grant applications. Please note that these letters should not be viewed as endorsements of the proposed research.
What if my funding application is not successful?
If your application is not funded and you wish to pursue a re-application for biospecimens with alternative funding, you must submit a new AgingResearchBiobank request. Due in part to the dynamic nature of the biospecimen inventory, any letter of biospecimen availability provided by AgingResearchBiobank is only valid for your original grant application. AgingResearchBiobank will re-assess biospecimen availability in the new request.
Obtaining Approved Biospecimen Requests
Who makes the decision about granting access to materials?
All applications are reviewed by the Biobank’s scientific review committees and judged on numerous criteria, including the qualifications of the researcher and the research environment, the significance and appropriateness of the proposed research, design of the proposed research, and ethical considerations including consistency with the terms of the informed consent obtained from the subjects. Final approval is determined by NIA.
If we were working together with a Study investigator, would this affect our situation and chances of accessing the data (including images) or biospecimens?
No. Each request is reviewed independently and all information is considered. If you want to include information that you are working with a Study investigator, the reviewers would consider that in the request. The information alone should not be a deciding factor for access to data (including images) or biospecimens.
While a study is ongoing, how do investigators gain access to biospecimens?
During the lifespan of the study, investigators should apply directly to the study group to propose an ancillary study.
I would like to receive more of the biospecimens that I have requested or additional biospecimens. What process should I follow?
Please submit a request for the additional materials, providing a justification and the original request number. In some cases, the documents submitted for the original request can be used for the new request as long as they are still current (e.g. IRB approval).
How do you interpret the following section in Funding Opportunity Announcements: "Applicants must include in this section a statement of how the proposed research fits within the limitations of the subjects' informed consent. Information about the informed consents for each study can be obtained from the AgingResearchBiobank."?
In general, biospecimens and data (including images) stored at the AgingResearchBiobank are consented for additional research; however, some consents are conditional and/or may require further review by the AgingResearchBiobank staff prior to approved release. All requests for biospecimens and data (including images) are carefully reviewed against the consent forms by the AgingResearchBiobank and NIA staff members to ensure adherence.
Under what conditions are biospecimens distributed?
In order to receive biospecimens, images, or data, the institution will have to sign an Outgoing Human Resources Transfer Agreement (OHRTA) for biospecimens or an Outgoing Human Data Transfer Agreement for data (including images) with NIA (https://sharing.nih.gov/data-management-and-sharing-policy/about-data-management-and-sharing-policies/data-management-and-sharing-policy-overview#after). The agreement will include certification that the project has IRB approval, that the investigators will only conduct the research consistent with the subjects' informed consent, and that researchers will not attempt to identify any individuals. In addition, the Agreement will forbid any redistribution of the materials by the investigator or institution and require the disposal of remaining biospecimens upon expiration of the OHRTA.
Once my request for biospecimens is approved, before pulling the biospecimens, will I be contacted regarding the method of biospecimen processing and shipment method?
If necessary, special processing requests may be taken into consideration. You will always be contacted before shipment of the biospecimens to verify shipping details and ensure availability to receive the shipment.
Once my request for biospecimens is approved, how long will it take for me to receive the biospecimens?
A biospecimen request can take up to several months to fulfill once the fully completed request is approved by NIA and the OHRTA/OHDTA is signed. Note that all requests require payment by the recipient before the request may be processed.
Biospecimen turnaround time depends on many factors, including:
- Does the request require relabeling of vials?
- How many biospecimens are being requested?
- Do they need to be aliquoted?
- Are the biospecimens stored in one freezer or scattered in several freezers?
- Are biospecimens being pulled from -80C freezers or liquid nitrogen freezers?
- Where will the biospecimens be shipped?
Obtaining Approved Data (including images) Requests
How will data packages (including images) be sent to me?
Once approved, you will receive a secure link through your data request where you can download the data package. You may not share the data (including images) with any other researcher not named in the Outgoing Human Data Transfer Agreement and will be required to either destroy the data (including images) or apply for an extension at the end of 12 months.
What if I need more time to complete my research?
If I have received several datasets, may I use one extension letter to cover all of them?
Yes, you can use the same letter of extension, but you will need to list all of the datasets in the letter.
I am unable to open a dataset I received/downloaded from the AgingResearchBiobank, what do I do next?
Please review the following questions. Send the answers via the Comments tab of your data request or through the Contact Us page (https://agingresearchbiobank.nia.nih.gov/contact/).
- Which study's data (including images) are you having problems with?
- Did you receive this dataset set from the AgingResearchBiobank?
- Are you having problems with any other datasets?
- Are you working with Windows PC or another operating system?
- What version of SAS are you using?
- Do you know the nature of the problem? Example: Cannot open because SAS format is missing; incompatible SAS version; or another specific error message.
- Are you trying to work with a different software tool such as R, SPSS, etc.?
IRB Approval
Is IRB approval required for internal analysis in an organization, or is IRB approval required only if the data analysis will be published?
For any level of access to the data (including images) you must have your institution's IRB approval or waiver. If you do not have an IRB, you must use an external IRB. This IRB step is required whether or not you publish your findings. Since the data we offer is provided in limited datasets and the data (including images) have been de-identified so there is no direct human-subject interaction, sometimes your IRB will consider a waiver. You may want to approach it from that standpoint.
I will have co-investigators from other institutions working with me on the dataset I am requesting. Does NIA need IRB approval from each institution separately, or do you just need the IRB approval from the Principal Requestor's institution?
All co-investigators who will receive the data (including images) need IRB approval to work with them. Similarly, each institution needs its own signed Agreement.
My IRB requires confirmation that all AgingResearchBiobank data are deidentified. Can the AgingResearchBiobank sign a Confidentiality Agreement so I can move forward with my request for NIA biospecimens and data?
NIA policy is that documents aside from the AgingResearchBiobank's own agreement will not be signed by NIA officials. Additionally, the AgingResearchBiobank provides limited datasets rather than completely de-identified data. One of the AgingResearchBiobank's tasks, as defined by NIA, is to develop systems to help ensure protection of the human subjects who contributed research biospecimens and/or data (including images) by maintaining the confidentiality of these subjects and by maintaining a searchable inventory of informed consents and NIA Approval Letters from biospecimen contributors.
Datasets, images, and biospecimens have been received without personal identifiers and thus are unlinked to the subjects. We do not accept any information, nor use any information collected, that would permit us as the keeper of a record system to establish the identity of a given subject or query the databases and retrieve information for an individual subject whose identity is known from some other source.
Traditional personal identifiers that may be utilized to establish the identity of individual subjects (e.g., surname, address, social security number, etc.) are never accepted by us when we receive materials from a study. Instead, we work with study's Data Coordinating Center and biospecimen repositories to develop an identifier code for each subject that will link the clinical and descriptive data to stored biospecimens. Once we receive biospecimens and data (including images) from study collections, we conduct a quality control process to ensure the integrity of the resources received and verify that no personally identifying information remains.
Producing Manuscripts using NIA Materials
If I produce a manuscript using NIA data, images, and/or biospecimens, am I required to acknowledge this?
Researchers producing manuscripts using NIA data and/or biospecimens are required to use the general AgingResearchBiobank acknowledgement.
Biospecimen and Data (including Images) Confidentiality
What provisions should be included about a repository in the informed consent for subjects?
NIA has developed model language for use in informed consents that describes a repository and explains what will happen to the biospecimens and data (including images) that are collected. The most important point is that a repository will not accept any personal identifiers on biospecimens or in the datasets or images. Your NIA Program/Project Officer can provide you with a copy of the model language. Also, visit the AgingResearchBiobank website for relevant information to help investigators develop resources management and sharing plans relevant information to help investigators develop resources management and sharing plans.
What subject or biospecimen identification code will the AgingResearchBiobank use?
The AgingResearchBiobank can use the study's assigned ID for each participant. In situations where this would be inappropriate, e.g., because the ID contains potential personal identifiers, the study should assign a different, masked, identifier and a link between this new de-identified ID and any stored biospecimens and/or images.
Does the AgingResearchBiobank maintain a Certificate of Confidentiality?
No. The Repository does not have a Certificate of Confidentiality because we do not accept any personally identifying information.
When biospecimens, images, or data are made available to requestors, will the actual name of the study clinic be released?
No. The study clinic is considered personally identifying information that could be used to identify subjects, especially when enrollment from a center was low or when used in combination with other characteristics. If a scientific need arises, a coded center may be released but the centers would not be identified by name or geographic location.
Biospecimen Ownership
Who owns the biospecimens and data (including images) submitted to the AgingResearchBiobank? Does the Institution submitting these resources maintain ownership or are they owned by NIA once they have been submitted?
The AgingResearchBiobank does not address its resources holdings in terms of "ownership". The National Institute on Aging (NIA) is the custodian of biospecimens and data (including images) from deposited studies. The NIA Official responsible for the AgingResearchBiobank is Rosaly Correa-de-Araujo, MD, MSc, PhD, FAC COR Level III who serves as its Program Officer/Contracting Officer Representative (COR). The Biobank and its scientific review committees assume responsibility for distributing resources to qualified investigators/institutions in accordance with applicable policies and procedures.