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Testosterone Treatment and Cognitive Function in Older Men With Low Testosterone and Age-Associated Memory Impairment.

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28241356
10.1001/jama.2016.21044
PMC5433758
JAMA
Feb. 21, 2017
Susan M Resnick17, Alvin M Matsumoto16, Alisa J Stephens-Shields3, Susan S Ellenberg3, Thomas M Gill13, Sally A Shumaker19, Debbie D Pleasants19, Elizabeth Barrett-Connor5, Shalender Bhasin18, Jane A Cauley4, David Cella6, Jill P Crandall15, Glenn R Cunningham9, Kristine E Ensrud8, John T Farrar1, Cora E Lewis14, Mark E Molitch12, Marco Pahor2, Ronald S Swerdloff11, Denise Cifelli1, Stephen Anton2, Shehzad Basaria19, Susan J Diem7, Christina Wang11, Xiaoling Hou3, Peter J Snyder10
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  • 1
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia.
  • 2
    Department of Aging and Geriatric Research, University of Florida, Gainesville.
  • 3
    Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia.
  • 4
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania.
  • 5
    Department of Internal Medicine and Division of Epidemiology, Department of Family Medicine and Public Health, University of California San Diego School of Medicine, La Jolla.
  • 6
    Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
  • 7
    Department of Medicine, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis.
  • 8
    Department of Medicine, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis15Minneapolis Veterans Affairs Health Care System. Minneapolis, Minnesota.
  • 9
    Departments of Medicine and Molecular and Cellular Biology, Division of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, Houston, Texas13Baylor St Luke's Medical Center, Houston, Texas14Department of Medicine, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis.
  • 10
    Division of Endocrinology, Diabetes, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia.
  • 11
    Division of Endocrinology, Harbor-University of California at Los Angeles Medical Center, Torrance21Los Angeles Biomedical Research Institute, Torrance, California.
  • 12
    Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
  • 13
    Division of Geriatric Medicine, Yale School of Medicine, New Haven, Connecticut.
  • 14
    Division of Preventive Medicine, University of Alabama at Birmingham.
  • 15
    Divisions of Endocrinology and Geriatrics, Albert Einstein College of Medicine, Bronx, New York.
  • 16
    Geriatric Research, Education, and Clinical Center, Department of Veterans Affairs Puget Sound Health Care System, Seattle, Washington3Division of Gerontology and Geriatric Medicine, Department of Internal Medicine, University of Washington School of Medicine, Seattle.
  • 17
    Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, Maryland.
  • 18
    Research Program in Men's Health, Aging, and Metabolism, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
  • 19
    Wake Forest School of Medicine, Winston-Salem, North Carolina.
Double-Blind Method, Gels, Executive Function, Intention to Treat Analysis, Memory Disorders, Memory, Mental Recall, Treatment Outcome, Male, Testosterone, Cognition, Androgens, Time Factors, Reference Values, Humans, Aged
P30 DK020541, UL1 TR000142, R01 AG037679, P60 DK079626, P30 DK079626, K07 AG043587, P30 AG021342, U01 AG030644, P30 AG031679, P30 AG028740
Resnick SM, Matsumoto AM, Stephens-Shields AJ, Ellenberg SS, Gill TM, Shumaker SA, Pleasants DD, Barrett-Connor E, Bhasin S, Cauley JA, Cella D, Crandall JP, Cunningham GR, Ensrud KE, Farrar JT, Lewis CE, Molitch ME, Pahor M, Swerdloff RS, Cifelli D, Anton S, Basaria S, Diem SJ, Wang C, Hou X, Snyder PJ. Testosterone Treatment and Cognitive Function in Older Men With Low Testosterone and Age-Associated Memory Impairment. JAMA 2017 Feb 21.

Abstract

Most cognitive functions decline with age. Prior studies suggest that testosterone treatment may improve these functions. To determine if testosterone treatment compared with placebo is associated with improved verbal memory and other cognitive functions in older men with low testosterone and age-associated memory impairment (AAMI). The Testosterone Trials (TTrials) were 7 trials to assess the efficacy of testosterone treatment in older men with low testosterone levels. The Cognitive Function Trial evaluated cognitive function in all TTrials participants. In 12 US academic medical centers, 788 men who were 65 years or older with a serum testosterone level less than 275 ng/mL and impaired sexual function, physical function, or vitality were allocated to testosterone treatment (n = 394) or placebo (n = 394). A subgroup of 493 men met criteria for AAMI based on baseline subjective memory complaints and objective memory performance. Enrollment in the TTrials began June 24, 2010; the final participant completed treatment and assessment in June 2014. Testosterone gel (adjusted to maintain the testosterone level within the normal range for young men) or placebo gel for 1 year. The primary outcome was the mean change from baseline to 6 months and 12 months for delayed paragraph recall (score range, 0 to 50) among men with AAMI. Secondary outcomes were mean changes in visual memory (Benton Visual Retention Test; score range, 0 to -26), executive function (Trail-Making Test B minus A; range, -290 to 290), and spatial ability (Card Rotation Test; score range, -80 to 80) among men with AAMI. Tests were administered at baseline, 6 months, and 12 months. Among the 493 men with AAMI (mean age, 72.3 years [SD, 5.8]; mean baseline testosterone, 234 ng/dL [SD, 65.1]), 247 were assigned to receive testosterone and 246 to receive placebo. Of these groups, 247 men in the testosterone group and 245 men in the placebo completed the memory study. There was no significant mean change from baseline to 6 and 12 months in delayed paragraph recall score among men with AAMI in the testosterone and placebo groups (adjusted estimated difference, -0.07 [95% CI, -0.92 to 0.79]; P = .88). Mean scores for delayed paragraph recall were 14.0 at baseline, 16.0 at 6 months, and 16.2 at 12 months in the testosterone group and 14.4 at baseline, 16.0 at 6 months, and 16.5 at 12 months in the placebo group. Testosterone was also not associated with significant differences in visual memory (-0.28 [95% CI, -0.76 to 0.19]; P = .24), executive function (-5.51 [95% CI, -12.91 to 1.88]; P = .14), or spatial ability (-0.12 [95% CI, -1.89 to 1.65]; P = .89). Among older men with low testosterone and age-associated memory impairment, treatment with testosterone for 1 year compared with placebo was not associated with improved memory or other cognitive functions. clinicaltrials.gov Identifier: NCT00799617.